Whisk the flour, garlic powder, smoked paprika, salt, pepper, and milk together to create a thick batter.
Coat the cauliflower florets first in the wet batter, then roll them evenly in the Panko breadcrumbs.
Arrange the breaded florets in a single layer in a preheated 375-degree air fryer basket and spray lightly with oil.
Air fry for 12 to 15 minutes, flipping halfway through, until golden and crispy.
Toss the hot, crispy florets immediately in a mixture of buffalo sauce and melted butter before serving.
