Macerate sliced strawberries with sugar and lemon juice for at least 20 minutes until juicy.
Beat cream cheese with powdered sugar and vanilla until smooth. Fold in half the whipped topping to make the cream layer.
Layer half the cake cubes in the bottom of a trifle bowl. Spoon half the strawberries and juices over the top.
Spread the cream cheese mixture evenly over the strawberry layer.
Add the remaining cake cubes, then top with remaining strawberries.
Finish with remaining whipped topping spread smoothly across the surface. Refrigerate at least 2 hours before serving.